Levaquin 500 mg

LEVAQUIN® is a imitation spread out-spectrum antibacterial spokesman into viva voce and intravenous oversight. Chemically, levofloxacin, a chiral fluorinated carboxyquinolone, is the clear (-)-(S)-enantiomer of the racemic medicine material ofloxacin.

The chemical denominate is (-)-(S)-9-fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid hemihydrate. Figure 1: The Chemical Structure of Levofloxacin LEVAQUIN® (levofloxacin) structural formula exemplar The experimental method is C18H20FN3O4 • ½ H2O and the molecular value is 370.38. Levofloxacin is a shine yellowish-white to yellow-pure crystal or crystalline gift. The molecule exists as a zwitterion at the pH conditions in the diminished intestine.
The statistics parade that from pH 0.6 to 5.8, the solubility of levofloxacin is essentially constant (nearly 100 mg/mL). Levofloxacin is considered soluble to freely soluble in this pH sweep, as defined around USP nomenclature. Above pH 5.8, the solubility increases right off the bat to its peak at pH 6.7 (272 mg/mL) and is considered free will soluble in this line up. Above pH 6.7, the solubility decreases and reaches a minimal value (thither 50 mg/mL) at a pH of close to 6.9. Levofloxacin has the potential to form stable coordination compounds with many metal ions. This in vitro chelation embryonic has the following structure society: Al+3 > Cu+2 > Zn+2 > Mg+2 > Ca+2.

Excipients and Description of Dosage Forms
Levaquin 500 mg Tablets are available as veil-coated tablets and bridle the following listless ingredients:
* 250 mg (as expressed in the anhydrous body): hypromellose, crospovidone, microcrystalline cellulose, magnesium stearate, polyethylene glycol, titanium dioxide, polysorbate 80 and mock red iron oxide.
* 500 mg (as expressed in the anhydrous sort): hypromellose, crospovidone, microcrystalline cellulose, magnesium stearate, polyethylene glycol, titanium dioxide, polysorbate 80 and false red and yellow iron oxides.
* 750 mg (as expressed in the anhydrous form): hypromellose, crospovidone, microcrystalline cellulose, magnesium stearate, polyethylene glycol, titanium dioxide, polysorbate 80.
Levaquin 500 mg Oral Solution, 25 mg/mL, is a multi-contemn self-preserving aqueous denouement of levofloxacin with pH ranging from 5.0 – 6.0. The appearance of LEVAQUIN® Oral Solution may pass over from forgiven yellow to clear greenish-yellow. This does not adversely affect product potency. LEVAQUIN® Oral Solution contains the following lackadaisical ingredients: sucrose, glycerin, sucralose, hydrochloric acid, purified modify, propylene glycol, artificial and actual flavors, benzyl alcohol, ascorbic acid, and caramel color. It may also restrict a figuring out of sodium hydroxide by reason of pH arrangement.

LEVAQUIN® Injection The hint of LEVAQUIN® Injection may variety from a clear yellow to a free greenish-yellow infusion. This does not adversely affect product potency. LEVAQUIN® Injection in Single-Use Vials is a unfruitful, preservative-unencumbered aqueous solution of levofloxacin in Water on Injection, with pH ranging from 3.8 to 5.8. LEVAQUIN® Injection Premix in Single-Use Flexible Containers is a pure, preservative-parole aqueous solution of levofloxacin with pH ranging from 3.8 to 5.8. This is a mitigate, non-pyrogenic, hardly isotonic premixed solution that contains levofloxacin in 5% Dextrose (D5W). Solutions of hydrochloric acid and sodium hydroxide may sire been added to adjust the pH.
The extensile container is fabricated from a exclusively formulated non-plasticized, thermoplastic copolyester (CR3). The amount of grade that can penetrate from the container into the overwrap is inadequate to use the colloid significantly. Solutions in contact with the manageable container can leach out indubitable of the container\'s chemical components in to a great extent diminished amounts within the finish period. The suitability of the container secular has been confirmed close tests in animals according to USP biological tests in the interest of fake containers.